Mesenchymal Tumors of the Mouse Urinary Bladder with Vascular and Smooth Muscle Differentiation
نویسندگان
چکیده
منابع مشابه
Chemically induced smooth muscle tumors of the mouse urinary bladder.
Occasional submucosal tumors of indeterminate origin and without definite connection to the overlying mucosa have been reported in mice given various carcinogenic agents. Two Swiss mice fed niridazole developed such tumors. Electron microscopy of 1 of the tumors revealed thin myofilaments with oval dense bodies, marginal dense plaques, and gap junctions, identifying the tumor as originating fro...
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Mouse bladder mesenchyme differentiates into smooth muscle under the influence of urothelium at gestational day 13.5 (E13.5). Sonic hedgehog (Shh) is considered to be the upstream gene arising from the urothelium, which induces smooth muscle in the peripheral bladder mesenchyme. We hypothesize differential gene expression across the full thickness of bladder mesenchyme as a function of proximit...
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Colorectal mesenchymal tumors are rare. Therefore, distinguishing between gastrointestinal stromal (GIST) and smooth muscle tumors is important. This study aimed to delineate the immunophenotype and prognostic factors of 75 colorectal mesenchymal tumors. Fifty-three GIST and 22 smooth muscle tumor specimens were included from 1986 to 2007. Forty of 53 GIST were initially diagnosed as smooth mus...
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1. We have used subtype selective P2X receptor antibodies to determine the expression of P2X(1 - 7) receptor subunits in the mouse urinary bladder. In addition we have compared P2X receptor mediated responses in normal and P2X(1) receptor deficient mice to determine the contribution of the P2X(1) receptor to the mouse bladder smooth muscle P2X receptor phenotype. 2. P2X(1) receptor immunoreacti...
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The sympathetic nervous system (SNS) is an important modulator of vascular smooth muscle (VSM) growth and function. Several lines of evidence suggest that the SNS also promotes VSM differentiation. The present study tests this hypothesis. Expression of smooth muscle myosin (SM2) and alpha-actin were assessed by Western analysis as indexes of VSM differentiation. SM2 expression (normalized to al...
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 1997
ISSN: 0192-6233,1533-1601
DOI: 10.1177/019262339702500304